Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

Authors:   S.A. Uspenskii, P.A. Khaptakhanova, A.A. Zaboronok, T.S. Kurkin, O.Yu. Volkova, L.V. Mechetina, A.V. Taranin, V.V. Kanygin, Matsumura Akira, S.Yu. Taskaev
Journal: Doklady Chemistry
https://doi.org/10.1134/S0012500820030027
Abstract: A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability