Fractionated BNCT for locally recurrent head and neck cancer: Experience from a phase I/II clinical trial at Tsing Hua Open-Pool Reactor

Authors:   Ling-Wei Wang,Yi-Wei Chen,Ching-Yin Ho,Yen-Wan Hsueh Liu,Fong-In Chou,Yuan-Hao Liu,Hong-Ming Liu,Jinn-Jer Peir,Shiang-Huei Jiang,Chi-Wei Chang,Ching-Sheng Liu,Shyh-Jen Wang,Pen-Yuan Chu,Sang-Hue Yen,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2013.11.134
Abstract: To introduce our experience of treating locally and regionally recurrent head and neck cancer patients with BNCT at Tsing Hua Open-Pool Reactor in Taiwan, 12 patients (M/F=10/2, median age 55.5 Y/O) were enrolled and 11 received two fractions of treatment. Fractionated BNCT at 30-day interval with adaptive planning according to changed T/N ratios was feasible, effective and safe for selected recurrent head and neck cancer in this trial.