2019 Article In-vivo Studies Radiobiology

Different oral cancer scenarios to personalize targeted therapy: Boron Neutron Capture Therapy translational studies

Therapeutic Delivery, 2019

Authors:   Andrea Hughes,Jessica Goldfinger,Iara Cruz,Emiliano Pozzi,Silvia Thorp,Paula Curotto,Marcela Garabalino,María Itoiz,Mónica Palmieri,Paula Ramos,Elisa Heber,Romina Aromando,David Nigg,Hanna Koivunoro,Verónica Trivillin,Amanda Schwint,
Journal: Therapeutic Delivery
Abstract: Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/or oral mucositis induced after treatment. Our group proposed the hamster oral cancer model to study the efficacy of BNCT and associated mucositis. Translational studies are essential to the advancement of novel boron delivery agents and targeted strategies. Herein, we review our work in the hamster model in which we studied BNCT induced mucositis using three different cancerization protocols, mimicking three different clinical scenarios. The BNCT-induced mucositis increases with the aggressiveness of the carcinogenesis protocol employed, suggesting that the study of different oral cancer patient scenarios would help to develop personalized therapies.