Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Authors:   Marcela Garabalino,Elisa Heber,Andrea Monti Hughes,Emiliano Pozzi,Ana Molinari,David Nigg,William Bauer,Verónica Trivillin,Amanda Schwint,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2013.11.118
Abstract: Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70–85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.