2014 Article Boron Determination ICNCT15 In-vivo Studies Radiobiology

Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model

Applied Radiation and Isotopes, 2014

Authors:   Tooru Andoh,Takuya Fujimoto,Tamotsu Sudo,Minoru Suzuki,Yoshinori Sakurai,Toshiko Sakuma,Hiroshi Moritake,Tohru Sugimoto,Tamotsu Takeuchi,Hiroshi Sonobe,Alan Epstein,Yoshinobu Fukumori,Koji Ono,Hideki Ichikawa,
Journal: Applied Radiation and Isotopes
Abstract: Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.