Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Authors:   Tooru Andoh,Takuya Fujimoto,Minoru Suzuki,Tamotsu Sudo,Yoshinori Sakurai,Hiroki Tanaka,Ikuo Fujita,Naomasa Fukase,Hiroshi Moritake,Tohru Sugimoto,Toshiko Sakuma,Hiroshi Sasai,Teruya Kawamoto,Mitsunori Kirihata,Yoshinobu Fukumori,Toshihiro Akisue,Koji Ono,Hideki Ichikawa,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.060
Abstract: Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-l-phenylalanine (l-BPA). Biodistribution data revealed tumor-selective accumulation of 10B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.