Penetration of Brain and Brain Tumor. VII. Tumor-Binding Sulfhydryl Boron Compounds

Authors:   A Soloway,H Hatanaka,M Davis
Journal: Journal of Medicinal Chemistry
https://doi.org/10.1021/jm00316a042
Abstract: The discovery of a class of boron compounds, containing the sulfhydryl group, which become fixed to tumor tissue and to serum proteins is presented. A comparison is made between the tosixity and tissue-binding properties of B12H12²⁻ and B12H11SH¹⁻. There are definite indications that SH groups on such anions are potent nucleophyles. Toxicity studies of this latter anion in rabbits are also discussed.