Effect of epithermal neutrons on viability of glioblastoma tumor cells in vitro

Authors:   L. A. Mostovich, N. V. Gubanova, O. S. Kutsenko, V. I. Aleinik, A. S. Kuznetsov, A. N. Makarov, I. N. Sorokin, S. Yu. Taskaev, G. I. Nepomnyashchikh, E. V. Grigoreva
Journal: Bulletin of Experimental Biology and Medicine
https://doi.org/10.1007/s10517-011-1304-1
Abstract: We studied in vitro effect of epithermal neutrons in various doses on viability of glioblastoma U87 tumor cells. Increasing the dose from 1.9 to 4.1 Sv promoted cell death. Cytofluorimetric analysis revealed no activation of apoptosis in the irradiated cells, which attested to necrotic death of the tumor cells exposed to epithermal neutron radiation.