Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model

Authors:   Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Toshihiro Akisue, Shinji Kawabata, Mitsunori Kirihata, Minoru Suzuki, Yoshinori Sakurai, Koji Ono, Yoshinobu Fukumori, Masahiro Kurosaka, Hideki Ichikawa
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2012.12.001
Abstract: Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono-L-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.