2011 Article Boron Determination ICNCT14 In-vitro Studies In-vivo Studies

Studies for the application of boron neutron capture therapy to the treatment of differentiated thyroid cancer

Applied Radiation and Isotopes, 2011

Authors:   A. Dagrosa,M. Carpano,M. Perona,L. Thomasz,S. Nievas,R. Cabrini,G. Juvenal,M. Pisarev,
Journal: Applied Radiation and Isotopes
Abstract: The aim of these studies was to evaluate the possibility of treating differentiated thyroid cancer by BNCT. These carcinomas are well controlled with surgery followed by therapy with 131I; however, some patients do not respond to this treatment. BPA uptake was analyzed both in vitro and in nude mice implanted with cell lines of differentiated thyroid carcinoma. The boron intracellular concentration in the different cell lines and the biodistribution studies showed the selectivity of the BPA uptake by this kind of tumor.