2020 Article In-vitro Studies Physics Radiobiology

Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration

Applied Radiation and Isotopes, 2020

Authors:   María Pedrosa-Rivera,M. Ruiz-Magaña,Patricia Álvarez,Ignacio Porras,Javier Praena,Manuel Sabariego,Ulli Köster,Michael Haertlein,V. Forsyth,Torsten Soldner,José Ramírez,Clara Jover,Daniel Jimena,Juan Osorio,Ian Postuma,Carmen Ruiz-Ruiz,
Journal: Applied Radiation and Isotopes
Abstract: The cold neutron beam at the PF1b line at the Institut Laue-Langevin (ILL), without fast neutrons and a low contribution of gamma rays, is a very suitable facility to measure cell damage following low-energy neutron irradiation. The biological damage associated with the thermal and the boron doses can be obtained in order to evaluate the relative biological effectiveness (RBE) for Boron Neutron Capture Therapy. Three different experiments were carried out on the A375 melanoma cell line: the first one in a hospital LINAC, to obtain the reference radiation data, and the other two at the ILL, in which the damage to cells with and without boron compounds added was measured.