Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme—Study design and current status report

Authors:   Shinji Kawabata,Shin-Ichi Miyatake,Ryo Hiramatsu,Yuki Hirota,Shiro Miyata,Yoko Takekita,Toshihiko Kuroiwa,Mitsunori Kirihata,Yoshinori Sakurai,Akira Maruhashi,Koji Ono,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.03.014
Abstract: Recently, we reported our clinical experiences of boron neutron capture therapy (BNCT) for the newly diagnosed glioblastoma. The major differences of our protocol from the other past studies were simultaneous use of both sodium borocapate and boronophenylalanine, and combination with fractionated X-ray irradiation. These results showed the efficacy of combination therapy with external beam X-ray irradiation and BNCT. For our future study, we planned the multi-centric phase II clinical study for newly diagnosed glioblastoma patients in Japan (OSAKA-TRIBRAIN0902, NCT00974987).