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2011 Article Biodistribution Biology ICNCT14

Low dose of gamma irradiation enhanced boronophenylalanine uptake in head and neck carcinoma cells for boron neutron capture therapy

Applied Radiation and Isotopes, 2011

Authors:   Y.C. Lin,S.J. Wang,H.P. Chung,H.M. Liu,F.I. Chou,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.02.028
Abstract: This study attempted to increase the boron uptake of human head and neck carcinoma SAS cells for BNCT by using a gamma dose of 0.1Gy for combined treatment. Intracellular boron concentrations in 25μgB/mL medium of BPA treated and BPA combined gamma-irradiation treated SAS cells were 73.8±1.73 and 95.15±1.36ppm, respectively. After neutron irradiation, the G2/M-phase cell populations of untreated, BPA treated and BPA combined gamma-irradiation treated SAS cells were 19.31±1.71%, 52.47±2.25% and 59.19±2.63%, respectively. Experimental results indicate that the low dose gamma radiation with combination BPA treatment has the highest killing rate after neutron irradiation. Capable of significantly increasing the G2/M arrest after neutron irradiation, the combined treatment of a low dose of gamma irradiation with 25 μgB/mL medium of BPA also provided a higher killing effect for BNCT.