Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy

Authors:   George Kabalka,Aarif Shaikh,Rolf Barth,Tianyao Huo,Weilian Yang,Pamela Gordnier,Subhash Chandra,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.03.035
Abstract: Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l-p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.