Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

Authors:   Sijumon Kunjachan,Alexandre Detappe,Rajiv Kumar,Thomas Ireland,Lisa Cameron,Douglas Biancur,Vincent Motto-Ros,Lucie Sancey,Srinivas Sridhar,G. Makrigiorgos,Ross Berbeco
Journal: Nano Letters
https://doi.org/10.1021/acs.nanolett.5b03073
Abstract: More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.