Day 0 – Friday 11th November – 10:30-12:30 UTC – Kick-off Party
10:30-11:00 UTC – Gathering: knowing the Venue and the virtual platform
11:00-12:00 UTC – Training with Virtual Chair – “How to use the platform”
Day 1 – Monday 14th November – 10:00-14:00 UTC
9:45 UTC – Pre-Meeting Training (Plenary room)
10:00-10:30 UTC – Welcome: CTF welcome, ISNCT president words, sponsors announcement (Plenary room)
10:30-11:00 UTC – Educational Lecture 1, BNCT Overview (Plenary room), “BNCT overview and opportunities“, Ignacio Porras, Department of Atomic, Molecular and Nuclear Physics, University of Granada, Spain
[ Chairs: Akira Matsumura and Agustina Portu]
11:00-11:15 UTC – Break
11:15-12:00 UTC – Talks 1, Physics: Accelerators&NeutronMeasurements (Room 1)
[Chairs: Alex Makarov and Hiroaki Kumada]
– “Design, Construction and Beam Commissioning of the 14 MeV Cyclotron for BNCT at CIAE“, Luyu Ji, China Institute of Atomic Energy
– “Development of Neutron Production Targets for AB-BNCT“, Pedro Augusto Gaviola, National Atomic Energy Commission (CNEA)
– “Neutron flux measurements in water phantom for BNСT“, Timofey Bykov, Budker Institute of Nuclear Physics
12:00-12:15 UTC – Break
12:15-13:30 UTC – Talks 2&3, parallel sessions (Room 1 and Room 2)
Room 1, Physics: Dosimetry I
[ Chairs: Naonori Hu and Sara González]
-“Measurement of the 14N(n,p) reaction at n_TOF – CERN: Implications in dosimetry of BNCT“, Pablo Torres-Sánchez, University of Granada
-“Development of improved hybrid dose calculation algorithm using MC method and diffusion equation“, Mai Nojiri, Graduate School of Engineering, Kyoto University
-“Microdosimetric analysis for Boron Neutron Capture Therapy through the Monte Carlo Track Structure simulation“, Yang Han, Nanjing University of Aeronautics and Astronautics & University of Pavia
-“Detailed dosimetry of mixed fields using BNCT for skin cancer treatments“, Jessica Riback, National Atomic Energy Commission (CNEA)
-“Monte Carlo simulations and in-vitro experiment to study if β-amyoid aggregates in Alzheimer’s disease can be damaged by low energy neutron capture reactions“, Valeria Pascali, University of Pavia & National Institute of Nuclear Physics (INFN)
Room 2, Biology
[ Chairs: María Pedrosa Rivera and Elena Delgrosso]
– “A veterinary case report: beagle with mastadenoma and nasal carcinoma treated by twice BNCT”, Zhendong Lin, Neuboron Bioscience Ltd.
– “Exploratory Study to Expand the Indication of Boron Neutron Capture Therapy Based on LAT1 Expression in Tumors”, Tsubasa watanabe, Institute for Integrated Radiation and Nuclear Science, Kyoto University
– “Study of the biological response in-vitro to determine the validity of extrapolating the compound-dependent factor from glioblastoma to head and neck cancer in BNCT”, Patricia Álvarez Rodíguez, Biomedical Research Center (CIBM), University of Granada
– “Evaluation of the effects of Boron Neutron Capture Therapy (BNCT) on proliferation of human keratinocytes in in-vitro epidermal models”, Stefania Ricci, University of Pavia
Day 2 – Tuesday 15th November – 10:00-14:00 UTC
10:00-10:30 UTC – Educational Lecture 2, Biology (Plenary room), “An updated overview of radiobiological studies using accelerator-based BNCT systems in the world”, Mitsuko Masutani, National Cancer Center Research Institute, Tokyo, Japan
[ Chairs: Andrea Monti Hughes and Fong-In Chou]
10:30-10:45 UTC – Break
10:45-12:00 UTC – Talks 1, Chemistry (Room 1)
[ Chairs: Taiki Morita and Takariho Nomoto]
– “Carborane containing hydrindones as individual pharmacophores for BNCT: synthesis and chemical reactivity“, Salida Irbayeva, The Institute of Nuclear Physics of the Republic of Kazakhstan
– “Development of Macrocyclic Polyamine-based Boron Delivery Agents for Neutron Capture Therapy“, Hiroki Ueda, Institute for Integrated Radiation and Nuclear Science, Kyoto University
– “New Boron Analogues of Amino Acid-based Agents for Boron Neutron Capture Therapy“, Yinghuai Zhu, Sunshine Lake Pharma Co. Ltd.
– “Selected 10-atom derivatives of mercaptoborate as substrates for the coupling reaction with the neurotransmitter protein”, Karolina Wójciuk, National Centre for Nuclear Research
-“Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging“, Vicenzo Amendola, University of Padova
12:00-12:15 UTC – Break
12:15-13:00 UTC – Poster session A, Biology and Physics (Poster Room)
13:00-14:00 UTC – Talks 2&3, parallel sessions (Room 1 and Room 2)
Room 1, Physics: Dosimetry II
[ Chairs: Sol Espain and Stuart Green]
– “Developments towards an adequate description of the dose-response relationship in the context of BNCT glioblastoma treatments“, Barbara Marcaccio, University of Pavia & National University of San Martín
– “A photon isoeffective brain dose model for BNCT based on dose–response assessment from an animal model and its impact on a retrospective analysis of glioblastoma treatment.“, Ana Mailen Dattoli Viegas, National Atomic Energy Commission (CNEA)
– “Study of intensity-modulated irradiation method for superficial tumors used accelerator-based BNCT“, Akinori Sasaki, Graduate School of Engineering, Kyoto University
– “Study of the biological effects in glioblastoma cell lines after exposure to low and high LET radiation appearing in BNCT therapy“, Martyna Araszkiewicz, University of Warsaw & National Centre for Nuclear Research
Room 2, Imaging: Medical Images
[ Chairs: Lucas Provenzano and Edyta Michaś-Majewska]
– “A Versatile Treatment Planning System for basic research in BNCT“, Antònia Verdera, University of Granada
– “A Self-Attention ResUnet to generate synthetic CT for MRI-guided BNCT “, Sheng Zhao, Nanjing University of Aeronautics and Astronautics
– “AI_MIGHT: Artificial Intelligence methods applied to medical images to enhance and personalize BNCT treatment planning“, Setareh Fatemi, National Institute of Nuclear Physics (INFN) Unit of Pavia
– “Automatic segmentation of Head & Neck tumours in CT images using an nnUNet to enhance BNCT TPS“, Francesco Morosato, National Institute of Nuclear Physics (INFN) Unit of Pavia & University of Pavia
Day 3 – Wednesday 16th November – 10:00-14:00 UTC
10:00-10:30 UTC – Educational Lecture 3, Physics (Plenary room), “The role and challenges of a Physicist in BNCT and What I learnt”, Yuan Hao Liu, Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China
[ Chairs: Silva Bortolussi and Hanna Koivunoro]
10:30-10:45 UTC – Break
10:45-12:00 UTC – Talks 1, Imaging: Detectors (Room 1)
[ Chairs: Pablo Torres Sánchez and Hiroki Tanaka]
– “Experimental Validation of a Spectroscopic and Imaging Detector Based on a LaBr3 Scintillator for Dose Monitoring in BNCT“, Anita Caracciolo, Politecnico di Milano
– “Prompt gamma imaging for BNCT using a Compton camera“, Kiran Nutter, University of Birmingham
– “Feasibility study of Prompt gamma-ray imaging by a Compton camera“, Makoro Sakai, Gunma University
– “Real-time Boron Concentration Monitoring Based on CdZnTe Compton Detector for the Accelerator-based Boron Neutron Capture Therapy: The First Experimental Study“, Changran Geng, Nanjing University of Aeronautics and Astronautics
-“Capability of FBP, MLEM and OSEM to monitor boron dose using a Compton Camera in Boron Neutron Capture Therapy“, Chunhui Gong, Nanjing University of Science and Technology
12:00-12:15 UTC – Break
12:15-13:30 UTC – Talks 2&3, parallel sessions (Room 1 and Room 2)
Room 1, Physics: Neutron Detectors
[ Chairs: Setareh Fatemi and Nikolaos Voulgaris]
– “Silicon carbide detectors for BNCT“, Aixeen Fontanilla, Frascati National Laboratory of National Institute of Nuclear Physics (INFN-LNF)
– “The BNCT neutron spectrometer NCT-WES: the NPL experimental validation campaign“, Alessandro Calamida, Frascati National Laboratory of National Institute of Nuclear Physics (INFN-LNF)
– “Development of a compact multi-elements activation neutron spectrometer for BNCT“, Ettore Mafucci, University of Torino
– “Validation of A Spectrometer To Measure Epi-thermal Neutrons Using A Position Sensitive Proportional Counter – Development of pencil-beam epi-thermal neutron source with a DT neutron source “, Yu Fujiwara, Osaka University
– “Measuring the near-target neutron field of a D–D fusion facility with the novel NCT-WES spectrometer“, Abner Iván Castro-Campoy, Frascati National Laboratory of National Institute of Nuclear Physics (INFN-LNF)
Room 2, Biology 2
[ Chairs: Hiroyuki Nakamura and Patricia Alvarez]
– “Efficacy of integrin targeting novel boron carrier for boron neutron capture therapy in F98 rat glioma bearing brain tumor models“, Kohei Tsujino, Osaka Medical and Pharmaceutical University
– “Novel precision BNCT strategy using a new boron agent targeting high-grade
pancreatic cancer“, Takya Fujimoto, Neutron Therapy Research Center, Okayama University
– “Breast cancer cells sensitization by gold nanoparticles in the case of Boron-Neutron Capture Therapy – the impact on cell cycle distribution and gamma-H2AX foci formation“, Wiktoria Krakowiak, Jan Kochanowski University in Kielce
– “Lithium neutron capture therapy as a potential melanoma treatment modality“, Anna Kasatova, Budker Institute of Nuclear Physics
13:30-14:00 UTC – Social activity (Social Room and Lobby)
[Host: Naonori Hu and Ian Postuma]
Day 4 – Thursday 17th November – 10:00-14:00 UTC
10:00-10:30 UTC – Educational Lecture 4, Chemistry (Plenary room), “Drug delivery systems for boron neutron capture therapy“, Takahiro Nomoto, Tokyo Institute of Technology, Tokyo, Japan
[ Chairs: Taiki Morita and Po Shen Pan]
10:30-10:45 UTC – Break
10:45-11:45 UTC – Talks 1, Biology III (Room 1)
[ Chairs: Natsuko Kondo and Anna Kasatova]
– “Oligo-Fucoidan enhances BPA-BNCT therapeutic effect on tumors: studies of boron biodistribution/microdistribution and microbiota in the hamster cheek pouch oral cancer model”, Andrea Monti Hughes, National Scientific and Technical Research Council (CONICET) & National Atomic Energy Commission (CNEA)
– “Therapeutic efficacy and radiotoxicity of BNCT employing Oligo-Fucoidan and Glutamine as adjuvants in an experimental model.”, Debora N Frydryk Benitez, National Atomic Energy Commission (CNEA)
– “Bystander effect and immune genes expression in HT29 colon adenocarcinoma cell line with Boron Neutron Capture Therapy.”, Yanina Ferreyra, National Atomic Energy Commission (CNEA)
11:45-12:15 UTC – Break
12:15-13:00 UTC – Poster session B, Chemistry + Imaging + Clinics + Physics (Poster Room)
13:00-14:00 UTC – Talks 2&3, parallel sessions (Room 1 and Room 2)
Room 1, Physics: Radioprotection & Gamma Detectors
[ Chairs: Valeria Mont and Evgeniia Sokolova]
– “Radioprotection assessment of an AB-BNCT Lab”, María Eugenia Capoulat, National Atomic Energy Commission (CNEA)
– “Radiation safety consideration, design, and commissioning of the Xiamen Humanity Hospital-Neuboron BNCT Center”, Caifeng Meng, Neuboron Therapy System Ltd.
– ”The gamma-ray dose evaluation with optically stimulated luminescent dosimeter of BeO in BNCT”, Nishiki Matsubayashi, Graduate School of Engineering, Kyoto University
– “Development of Real-time Gamma-ray Spectrum / Dose Monitor -Investigation of true real-time convergence-”, Nikolaos Voulgaris, Osaka University
Room 2, Imaging: Autoradiography
[ Chairs: Ian Postuma and Barbara Marcaccio]
– “Machine learning based image classification in neutron autoradiography”, Julia Sabrina Viglietti, National Atomic Energy Commission (CNEA)
– “Optical density analysis in autoradiographic images for the study of preferential boron uptake in broncho-vascular tree and its effects on lung dosimetry”, María Sol Espain, National Scientific and Technical Research Council (CONICET) & National Atomic Energy Commission (CNEA)
– ”Development of indirect neutron radiography for BNCT beam characterization at Xiamen Humanity Hospital-Neuboron BNCT Center”, Xinyu Wang, Nanjing University of Aeronautics and Astronautics
– “Fundamental Study on T/N Ratio Determination by Ex-vivo Macro-imaging of BPA with A brain tumor model rat for BNCT”, Yugo Tokumaru, Osaka university
Day 5 – Friday 18th November – 10:00-14:00 UTC
10:00-10:30 UTC – Educational Lecture 5, Clinics (Plenary room), “BNCT for malignant brain tumors, reactor to accelerator”, Shin-Ichi Miyatake, Kansai Medical BNCT Center, Osaka Medical and Pharmaceutical University, Japan
[ Chairs: Woo Kim and Minoru Suzuki]
10:30-10:45 UTC – Break
10:45-11:45 UTC – Talks 1, Clinics (Room 1)
[ Chairs: Woo Kim and Minoru Suzuki]
– “A Flexible Patient Position Method Combined with Treatment Planning System NeuMANTA for BNCT”, Jiang Chen, Neuboron Therapy System Ltd.
– “Promoting the use of a common language for specifying and reporting the doses in Boron Neutron Capture Therapy”, Yi-Chiao Teng, Neuboron Therapy System Ltd.
– “Interim results of accelerator based BNCT RCT for refractory high-grade meningiomas”, Shin-Ichi Miyatake, Kansai BNCT Medical Center & Osaka Medical and Pharmaceutical University
– “Should Canada Join the Preclinical and Clinical Research of Boron Neutron Capture Therapy?”, Ming Pan, Windsor Regional Hospital Cancer Program
11:45-12:15 UTC – Social activity (Social Room)
[Host: Setareh Fatemi]
12:15-12:30 UTC – Break12:30-13:30 UTC – Closure (Plenary room): Awards announcement, next meeting presentation and Closure.
Poster sessions
Poster Session A – Tuesday 15th November – 12:15-13:00
Biology
– “Targeting M-MDSC enhances the therapeutic effect of BNCT in HNSCC“, Chun-Hsiang Chang
– “Study Of Microglia In Alzheimer’s Disease: Chemical Structure And Modeling Of TREM2“, Elena Mishina
– “Boron neutron capture therapy as an effective treatment modality against human colorectal adenocarcinoma “, Anna Kasatova
– “Boron delivery using cerebrospinal fluid (CSF) circulation to brain cells in brain tumor model rats for BNCT －Ex vivo imaging of BPA using MALDI mass spectrometry imaging－“, Sachie Kusaka
– “NEUTRON CAPTURE THERAPY (NCT) AGAINST A NEW TARGET: THE ALZHEIMER’S DISEASE“, Sebastiano Maria Salomone Micocci
– “3D bioprinted osteosarcoma model for experimental Boron Neutron Capture Therapy (BNCT) applications: methodological aspects“, Elena Delgrosso
– “Study of sulfur compounds as potential coadjuvants in Boron Neutron Capture Therapy” María Isabel Porras Quesada
– “Survival of human melanoma A375 cells after irradiation with thermal and near-epithermal fast neutron beam“, Cristina Méndez Malagón
Physics
– “Study of impurity accumulation in a lithium neutron-generating target“, Marina Bikchurina
– “Design Study of Real-time Absolute Epi-thermal Neutron Flux Intensity Monitor using Scintillation Detectors” Jiye Qiu
– “High-accuracy dose calculation for brain tumor BNCT treatment plan with NECP-MCX” Hey Peng Physics
– “RBE estimation of BNCT based on MK model with optimized parameters“, Wentao Peng
– “Cold neutron producing in the compact accelerator-based neutron source“, Viktoriia Konovalova
– “Experimental verification of real-time γ-ray energy spectrum and dose monitor up to 3 MeV“, Hayato Sumi
– “Doses-distribution measurement for boron neutron capture therapy in a water phantom using a scintillator detector“, Ibrahim Ibrahim
– “Fast Neutron and Gamma-ray Absorbed Dose Rate Measurements in Reference Phantom Based on Twin Ionization Chambers“, Bin Shi
– “Removal-Diffusion theory to calculate neutron distributions for dose determination in BNCT“, Andres Felipe Orjuela Rincon
– “Gamma-Ray Dosimeter Development Using Radio-Photoluminescence Glass Dosimeter (RPLGD) in Neutron/Gamma-Ray Mixed Field for BNCT – Control of the response of RPLGD with a shielding filter –“, Masaya Matsuki
– “Design of BNCT-SPECT by PHITS – Aiming at high-precision measurement by analyzing crosstalk phenomena –“, Mikito Yagura
– “Measurement of the spatial distribution of neutrons and gamma radiation in a water phantom“, Enkhtsetseg Byambatseren
Poster Session B – Thursday 17th November – 12:15-13:00
Chemistry
– “Development of composite nanomaterials as boron carriers in BNCT“, Maria Paola Demichelis
– “Formulation and optimization of PLGA nanoparticles for boron neutron capture therapy using Box-Behnken design“, Maxim Kimenko
– “Large scale preparation of dodecaborane for synthesis of BNCT drug intermediates“, Qihui Shen
– “The first antisense oligonucleotides anti-EGFR decorated with boron clusters (B-ASO) for BNCT“, Damian Kaniowski
Clinics/Med Phys
– “A Comparison of Dose Error Effected by SSD and Collimator Apertures Size” Yi-Chiao Teng
Imaging
“Evaporation coefficient as a correction factor for boron quantification in histological sections through neutron autoradiography technique“, María Sol Espain
– “IMPLEMENTATION OF AUTOMATION SYSTEM AND VISUALIZATION OF EXPERIMENTAL DATA IN REAL TIME AT THE BNCT FACILITY BINP“, Aleksey Koshkarev
– “Feature detection algorithms comparison for quantitative neutron capture radiography track detection“, Enrico Re
Physics
– “The Design of γ-ray Spectrometer for BNCT Therapeutic Beam” Shufeng Zhang
– “Dosimetric study of prostate cancer using BNCT based on the Nuclear Research Reactor NUR: Monte Carlo Simulation“, Radhia Boumghar
– “Overlapping inspection of human tissue and collimator in BNCT planning of radiotherapy“, Wan-Bing Zhong
– “The design of mouse and rat holders used for preclinical animal experiments in XHH BNCT Center“, Xingyan Liu
– “Dosimetry measurements at the Finnish accelerator-based BNCT facility“, Emmi Kirjanen
– “Development of the extended collimator in BNCT for Head and Neck cancer“, Yinuo Li
– “Current status of BNCT for FDS group“, Xiang Li
– “Image Reconstruction with Limited-view-angle Projection Data for BNCT-SPECT ―Establishment of the Mock-up System and Validation of the Response Function―“, Fan Lu
– “Design, engineering implementation, and beam parameters of clinical BNCT neutron beam“, Diyun Shu
– “Characterization of the hydraulic rabbit in the Maria Research Reactor for biomedical irradiation in BNCT therapy“, Michal Dorosz
– “Tissue uptake of novel BNCT compounds in a mouse model, with pharmacokinetic and dosimetric extrapolation to human treatment“, Warren Kilby
– “Using RBS for in situ characterization of BNCT lithium targets“, Aleksandr Makarov