In vivo Accelerator-based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series

Authors:   V. Kanygin, A. Kichigin, A. Zaboronok, A. Kasatova, E. Petrova, A. Tsygankova, E. Zavjalov, B. Mathis, S. Taskaev.
Journal: Biology
https://doi.org/10.3390/biology11010138
Abstract: Background: accelerator-based neutron sources are a new frontier for BNCT but many technical issues remain. We aimed to study such issues and results in larger-animal BNCT (cats and dogs) with naturally occurring, malignant tumors in different locations as an intermediate step in translating current research into clinical practice. (2) Methods: 10 pet cats and dogs with incurable, malignant tumors that had no treatment alternatives were included in this study. A tandem accelerator with vacuum insulation was used as a neutron source. As a boron-containing agent,10B-enriched sodium borocaptate (BSH) was used at a dose of 100 mg/kg. Animal condition as well as tumor progression/regression were monitored. (3) Results: regression of tumors in response to treatment, improvements in the overall clinical picture, and an increase in the estimated duration and quality of life were observed. Treatment-related toxicity was mild and reversible. (4) Conclusions: our study contributes to preparations for human BNCT clinical trials and suggests utility for veterinary oncology. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.