Article Biology In-vivo Studies Year 2022

Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice

Bulletin of Experimental Biology and Medicine, 2022

Authors:   Kanygin V.V., Kasatova A.I., Zavjalov E.L., Razumov I.A., Kolesnikov S.I., Kichigin A.I., Solov’eva O.I., Tsygankova A.R., Taskaev S. Yu., Kasatov D.A., Sycheva T.V., Byvaltsev V.A.
Journal: Bulletin of Experimental Biology and Medicine
Abstract: Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).