Synthesis and in vitro evaluation of thiododecaborated α,α- Cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy

Authors:   Yoshihide Hattori,Shintaro Kusaka,Mari Mukumoto,Miki Ishimura,Yoichiro Ohta,Hiroshi Takenaka,Kouki Uehara,Tomoyuki Asano,Minoru Suzuki,Shin Masunaga,Koji Ono,Shinji Tanimori,Mitsunori Kirihata
Journal: Amino Acids
https://doi.org/10.1007/s00726-014-1829-5
Abstract: Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, $alpha$, $alpha$-cycloalkyl amino acids containing thiododecaborate ([B12H11]2–S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate $alpha$, $alpha$-cycloalkyl amino acids were synthesized, and biological evaluation of the boron compounds as boron carrier for BNCT was carried out.