Article Biodistribution Biology In-vivo Studies Year 2012

Selective uptake of boronophenylalanine by glioma stem/progenitor cells

Applied Radiation and Isotopes, 2012

Authors:   Ting Sun,Youxin Zhou,Xueshun Xie,Guilin Chen,Bin Li,Yongxin Wei,Jinming Chen,Qiang Huang,Ziwei Du
Journal: Applied Radiation and Isotopes
Abstract: The success of boron neutron capture therapy (BNCT) depends on the amount of boron in cells and the tumor/blood and tumor/(normal tissue) boron concentration ratios. For the first time, measurements of boron uptake in both stem/progenitor and differentiated glioma cells were performed along with measurements of boron biodistribution in suitable animal models. In glioma stem/progenitor cells, the selective accumulation of boronophenylalanine (BPA) was lower, and retention of boron after BPA removal was longer than in differentiated glioma cells in vitro. However, boron biodistribution was not statistically significantly different in mice with xenografts. {textcopyright} 2012 Elsevier Ltd.