Boronated DNA-binding compounds as potential agents for boron neutron capture therapy

Authors:   Ellen L Crossley, Erin J Ziolkowski, Jeffrey A Coderre, Louis M Rendina
Journal: Mini-Reviews in Medicinal Chemistry
https://doi.org/10.2174/138955707780059808
Abstract: Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.