2011 Article Biology Boron Determination Chemistry ICNCT14 In-vitro Studies In-vivo Studies Middle Boron compounds

Tumor accumulation of ε-poly-lysines-based polyamines conjugated with boron clusters

Applied Radiation and Isotopes, 2011

Authors:   Masayuki Umano,Kazuhiro Uechi,Takatoshi Uriuda,Sayuri Murayama,Hideki Azuma,Atsuko Shinohara,Young Liu,Koji Ono,Mitsunori Kirihata,Hironobu Yanagie,Takeshi Nagasaki,
Journal: Applied Radiation and Isotopes
Abstract: Boron Neutron Capture Therapy (BNCT) is one of the potent cancer radiotherapies using nuclear reaction between 10B atoms and the neutron. Whether BNCT will succeed or not depends on tumor selective delivery of 10B compounds. ε-Poly-L-lysine is a naturally occurring polyamine characterized by the peptide linkages between the carboxyl and ε-amino groups of L-lysine. Because of high safety ε-PLL is applied practically as a food additive due to its strong antimicrobial activity. In this study, we focus on a development of a novel polymeric delivery system for BNCT using biodegradable ε-PLL conjugated with 10B-containing clusters (BSH). This polymeric boron carrier will be expected to deliver safely and efficiently into tumor tissues based on Enhanced Permeability and Retention (EPR) effect.