2011 Article Biodistribution Biology ICNCT14

Sodium mercaptoundecahydro-closo-dodecaborate (BSH), a boron carrier that merits more attention

Applied Radiation and Isotopes, 2011

Authors:   Andrea Wittig,Finn Stecher-Rasmussen,Ralf Hilger,Jürgen Rassow,Pierluigi Mauri,Wolfgang Sauerwein,
Journal: Applied Radiation and Isotopes
Abstract: Boron neutron capture therapy relies on the preferential delivery of a 10B-compound to tumor cells. The BSH-biodistribution was investigated in nu/nu mice and human patients. The boron concentration was measured with prompt gamma ray spectroscopy. BSH accumulates to a very low extent not only in brain, but also in fat tissue, bone and muscle, which makes BSH an interesting drug not only for brain lesions but also for tumors located at the extremities. The differential uptake in different organs indicates a complex mechanism.