Reference systems for the determination of 10B through autoradiography images: Application to a melanoma experimental model

Authors:   A. Portu,M. Carpano,A. Dagrosa,S. Nievas,E. Pozzi,S. Thorp,R. Cabrini,S. Liberman,G. Saint Martin,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.02.049
Abstract: The amount of 10B in tissue samples may be determined by measuring the track density in the autoradiography image produced on a nuclear track detector. Different systems were evaluated as reference standards to be used for a quantitative evaluation of boron concentration. The obtained calibration curves were applied to evaluate the concentration of 10B in melanoma tumour of NIH nude mice after a biodistribution study. The histological features observed in the tissue sections were accurately reproduced by the autoradiography images.