2015 Article Case Report ICNCT16 Recurrences Toxicity

Radiation-induced meningiomas after BNCT in patients with malignant glioma

Applied Radiation and Isotopes, 2015

Authors:   T. Kageji,S. Sogabe,Y. Mizobichi,K. Nakajima,N. Shinji,Y. Nakagawa,
Journal: Applied Radiation and Isotopes
Abstract: Of the 180 patients with malignant brain tumors whom we treated with boron neutron capture therapy (BNCT) since 1968, only one (0.56%) developed multiple radiation-induced meningiomas. The parasagittal meningioma that had received 42Gy (w) for BNCT showed more rapid growth on Gd-enhanced MRI scans and more atypical features on histopathologic studies than the temporal convexity tumor that had received 20Gy (w). Long-term follow up MRI studies are necessary in long-survivors of malignant brain tumors treated by BNCT.