Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

Authors:   Takuya Fujimoto,Tooru Andoh,Tamotsu Sudo,Ikuo Fujita,Naomasa Fukase,Tamotsu Takeuchi,Hiroshi Sonobe,Masayoshi Inoue,Tkanori Hirose,Toshiko Sakuma,Hiroshi Moritake,Tohru Sugimoto,Teruya Kawamoto,Yoshinobu Fukumori,Satomi Yamamoto,Shinji Atagi,Yoshinori Sakurai,Masahiro Kurosaka,Koji Ono,Hideki Ichikawa,Minoru Suzuki,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.059
Abstract: Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.