Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a 10BSH-containing WOW emulsion

Authors:   Hironobu Yanagie,Syushi Higashi,Koji Seguchi,Ichiro Ikushima,Mituteru Fujihara,Yasumasa Nonaka,Kazuyuki Oyama,Syoji Maruyama,Ryo Hatae,Minoru Suzuki,Shin-ichiro Masunaga,Tomoko Kinashi,Yoshinori Sakurai,Hiroki Tanaka,Natsuko Kondo,Masaru Narabayashi,Tetsuya Kajiyama,Akira Maruhashi,Koji Ono,Jun Nakajima,Minoru Ono,Hiroyuki Takahashi,Masazumi Eriguchi,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2014.01.014
Abstract: A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a 10BSH-containing water-in-oil-in-water emulsion (10BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that 10BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.