Localized radiation necrosis model in mouse brain using proton ion beams

Authors:   Natsuko Kondo,Yoshinori Sakurai,Takushi Takata,Nobuhiko Takai,Yosuke Nakagawa,Hiroki Tanaka,Tsubasa Watanabe,Kyo Kume,Taichiro Toho,Shin-ichi Miyatake,Minoru Suzuki,Shin-ichiro Masunaga,Koji Ono,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.032
Abstract: Brain radiation necrosis is the most serious late adverse event that occurs after 6 months following radiation therapy. Effective treatment for this irreversible brain necrosis has not been established yet. This study tries to establish brain radiation necrosis mouse model using proton or helium beam. The right cerebral hemispheres of C57BL/6J mouse brains were irradiated at doses of 40, 50, 60Gy with charged particles. In 60Gy group, brain necrosis that recapitulates human disease was detected after 8 months.