Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE)

Authors:   Yohei Yamamoto,Tetsuya Yamamoto,Yukichi Horiguchi,Makoto Shirakawa,Takahiro Satoh,Masashi Koka,Yukio Nagasaki,Kei Nakai,Akira Matsumura,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2013.12.037
Abstract: To clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C82 and subcutaneous tumors were taken from 48h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C82 is potentially useful Gd carrier for NCT.