2014 Article ICNCT15 In-vivo Studies Toxicity

Glioblastoma, brain metastases and soft tissue sarcoma of extremities: Candidate tumors for BNCT

Applied Radiation and Isotopes, 2014

Authors:   Andrea Wittig,Raymond Moss,Wolfgang Sauerwein,
Journal: Applied Radiation and Isotopes
Abstract: 10B-concentration ratios between human glioblastoma multiforme (U87MG), sarcoma (S3) and melanoma (MV3) xenografted in nu/nu mice and selected normal tissues were investigated to test for preferential 10B-accumulation. Animals received BSH, BPA or both compounds sequentially. Mean 10B-concentration ratios between tumor and normal tissues above 2 were found indicating therapeutic ratios. In addition to glioblastoma, brain metastases and soft tissue sarcoma appear to be promising targets for future BNCT research.