From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy

Authors:   Rolf Barth,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.06.016
Abstract: In this report five examples have been selected to illustrate how studies in experimental animals have lead directly to clinical implementation. These include (1) the use of BSH as a boron delivery agent for BNCT of patients with brain tumors, and more specifically gliomas; (2) the use of BPA as a delivery agent for BNCT for patients with melanomas and (3) its subsequent use for BNCT of patients with gliomas; (4) optimization of the delivery of BPA in patients with gliomas; and finally (5) the combination of BSH and BPA with BNCT alone or together with X-irradiation to treat patients with gliomas.