2014 Article Beams Dosimetry ICNCT15 Physics

Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography

Applied Radiation and Isotopes, 2014

Authors:   H. Tanaka,Y. Sakurai,M. Suzuki,S. Masunaga,T. Mitsumoto,Y. Kinashi,N. Kondo,M. Narabayashi,Y. Nakagawa,T. Watanabe,N. Fujimoto,A. Maruhashi,K. Ono,
Journal: Applied Radiation and Isotopes
Abstract: It is important to measure the microdistribution of 10B in a cell to predict the cell-killing effect of new Boron Compounds in the field of boron neutron capture therapy. Alpha autoradiography has generally been used to detect the microdistribution of 10B in a cell. Although it has been performed using a reactor-based neutron source, the realization of an accelerator-based thermal neutron irradiation field is anticipated because of its easy installation at any location and stable operation. Therefore, we propose a method using a cyclotron-based epithermal neutron source in combination with a water phantom to produce a thermal neutron irradiation field for alpha autoradiography. This system can supply a uniform thermal neutron field with an intensity of 1.7×109 (cm−2s−1) and an area of 40mm in diameter. In this paper, we give an overview of our proposed system and describe a demonstration test using a mouse liver sample injected with 500mg/kg of boronophenyl-alanine.