Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Authors:   Lin-Chiang Sherlock Huang,Wen-Yuan Hsieh,Jiun-Yu Chen,Su-Chin Huang,Jen-Kun Chen,Ming-Hua Hsu,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2013.12.025
Abstract: We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.