Dose estimation of animal experiments at the THOR BNCT beam by NCTPlan and Xplan

Authors:   Yuan‐Hao Liu,Pei‐Yi Lee,Yu-Chuan Lin,Fong-In Chou,Wei-Lin Chen,Yu-Shiang Huang,Shiang‐Huei Jiang,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2014.01.032
Abstract: Dose estimation of animal experiments affects many subsequent derived quantities, such as RBE and CBE values. It is important to ensure the trustiness of calculated dose of the irradiated animals. However, the dose estimation was normally calculated using simplified geometries and tissue compositions, which led to rough results. This paper introduces the use of treatment planning systems NCTplan and Xplan for the dose estimation. A mouse was taken as an example and it was brought to hospital for micro-PET/CT scan. It was found that the critical organ doses of an irradiated mouse calculated by simplified model were unreliable in comparison to Xplan voxel model. The difference could reach the extent of several tenths percent. It is recommended that a treatment planning system should be introduced to future animal experiments to upgrade the data quality.