2011 Article Chemistry Drug Delivery System ICNCT14

Design, development and characterization of multi-functionalized gold Nanoparticles for biodetection and targeted boron delivery in BNCT applications

Applied Radiation and Isotopes, 2011

Authors:   Subhra Mandal,Gerald Bakeine,Silke Krol,Cinzia Ferrari,Anna Clerici,Cecilia Zonta,Laura Cansolino,Francesca Ballarini,Silva Bortolussi,Subrina Stella,Nicoletta Protti,Piero Bruschi,Saverio Altieri,
Journal: Applied Radiation and Isotopes
Abstract: The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold Nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the Nanoparticles in cancer cells that are known to overexpress folate receptors.