2014 Article Dosimetry ICNCT15 In-vivo Studies Physics Radiobiology

Design, construction and application of a neutron shield for the treatment of diffuse lung metastases in rats using BNCT

Applied Radiation and Isotopes, 2014

Authors:   A. Razetti,R.O. Farías,S.I. Thorp,V.A. Trivillin,E.C.C. Pozzi,P. Curotto,A.E. Schwint,S.J. González,
Journal: Applied Radiation and Isotopes
Abstract: A model of multiple lung metastases in BDIX rats is under study at CNEA (Argentina) to evaluate the feasibility of BNCT for multiple, non-surgically resectable lung metastases. A practical shielding device that comfortably houses a rat, allowing delivery of a therapeutic, uniform dose in lungs while protecting the body from the neutron beam is presented. Based on the final design obtained by numerical simulations, the shield was constructed, experimentally characterized and recently used in the first in vivo experiment at RA-3.