Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Authors:   T. Kageji,Y. Mizobuchi,S. Nagahiro,Y. Nakagawa,H. Kumada,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.05.029
Abstract: The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998. The median survival time (MST) of BNCT was 19.5 months, and 2-year, 3-year and 5-year survival rates were 26.1%, 17.4% and 5.8%, respectively. This clinical result of BNCT in patients with GBM is superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment.