2011 Article ICNCT14 In-vitro Studies Radiobiology

Boron neutron capture therapy induces cell cycle arrest and DNA fragmentation in murine melanoma cells

Applied Radiation and Isotopes, 2011

Authors:   F. Faião-Flores,P.R.P. Coelho,J. Arruda-Neto,Durvanei Maria,
Journal: Applied Radiation and Isotopes
Abstract: The melanoma is a highly lethal skin tumor, with a high incidence. Boron Neutron Capture Therapy (BNCT) is a radiotherapy which combines Boron with thermal neutrons, constituting a binary system. B16F10 melanoma and L929 fibroblasts were treated with Boronophenylalanine and irradiated with thermal neutron flux. The electric potential of mitochondrial membrane, cyclin D1 and caspase-3 markers were analyzed. BNCT induced a cell death increase and cyclin D1 amount decreased only in B16F10 melanoma. Besides, there was not caspase-3 phosphorylation.