Boron containing magnetic Nanoparticles for neutron capture therapy – an innovative approach for specifically targeting tumors

Authors:   Rainer Tietze,Harald Unterweger,Stephan Dürr,Stefan Lyer,Lea Canella,Petra Kudejova,Franz Wagner,Winfried Petry,Nicola Taccardi,Christoph Alexiou,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.028
Abstract: The selective delivery of 10B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic Nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted 10B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and Nanoparticles as well as varying three-dimensional arrangements have been performed.