Authors: Kei Nakai,Yohei Yamamoto,Emiko Okamoto,Tetsuya Yamamoto,Fumiyo Yoshida,Akira Matsumura,Naoto Yamada,Akane Kitamura,Masashi Koka,Takahiro Satoh,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.035
Abstract: The neutron source of BNCT is currently changing from reactor to accelerator, but peripheral facilities such as a dose-planning system and blood boron analysis have still not been established. To evaluate the potential application of particle-induced gamma-ray emission (PIGE) for boron measurement in clinical boron neutron capture therapy, boronophenylalanine dissolved within a cell culture medium was measured using PIGE. PIGE detected 18μgB/mL f-BPA in the culture medium, and all measurements of any given sample were taken within 20min. Two hours of f-BPA exposure was required to create a boron distribution image. However, even though boron remained in the cells, the boron on the cell membrane could not be distinguished from the boron in the cytoplasm.
Categories
Boron analysis for neutron capture therapy using particle-induced gamma-ray emission
Applied Radiation and Isotopes, 2015