2015 Article Boron Determination ICNCT16 Physics

Boron analysis for neutron capture therapy using particle-induced gamma-ray emission

Applied Radiation and Isotopes, 2015

Authors:   Kei Nakai,Yohei Yamamoto,Emiko Okamoto,Tetsuya Yamamoto,Fumiyo Yoshida,Akira Matsumura,Naoto Yamada,Akane Kitamura,Masashi Koka,Takahiro Satoh,
Journal: Applied Radiation and Isotopes
Abstract: The neutron source of BNCT is currently changing from reactor to accelerator, but peripheral facilities such as a dose-planning system and blood boron analysis have still not been established. To evaluate the potential application of particle-induced gamma-ray emission (PIGE) for boron measurement in clinical boron neutron capture therapy, boronophenylalanine dissolved within a cell culture medium was measured using PIGE. PIGE detected 18μgB/mL f-BPA in the culture medium, and all measurements of any given sample were taken within 20min. Two hours of f-BPA exposure was required to create a boron distribution image. However, even though boron remained in the cells, the boron on the cell membrane could not be distinguished from the boron in the cytoplasm.