BNCT treatment planning of recurrent head-and-neck cancer using THORplan

Authors:   Hui-Ting Yu,Yen-Wan Liu,Tzung-Yi Lin,Ling-Wei Wang,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.02.041
Abstract: A cooperation program on Boron Neutron Capture Therapy (BNCT) between National Tsing Hua University (NTHU) and Taipei Veterans General Hospital (TPEVGH) was established in 2008. Clinical trial of recurrent head-and-neck cancer is the goal of the program. In this study, treatment plannings of two head-and-neck cancer cases are performed using treatment planning system THORplan developed at NTHU of Taiwan. The patients are assumed to be irradiated under current THOR epithermal neutron beam. The prescription dose is 20Gy-Eq for at least 80% of tumor volume. The irradiation time to reach the target tumor dose can be kept within 1h. The skin dose is within the limiting dose of 11Gy-Eq. The spinal cord dose is well within the limiting dose of 10Gy-Eq. The use of an extension collimator for easier patient positioning is helpful in reducing the dose of eye lens to within the dose limit of 5Gy-Eq. The irradiation time, however, will increase slightly due to the increase of source-to-tumor distance. The CPU time for treatment planning calculation is ∼10h. With the use of user friendly treatment planning system THORplan, dose planning for BNCT at THOR can be easily performed.