BNCT treatment planning for superficial and deep-seated tumors: Experience from clinical trial of recurrent head and neck cancer at THOR

Authors:   Yen-Wan Liu,Chih-Ting Chang,Lan-Yun Yeh,Ling-Wei Wang,Tzung-Yi Lin,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.08.002
Abstract: Under the collaboration between National Tsing Hua University and Taipei Veterans General Hospital, clinical trial of recurrent head-and-neck cancer by Boron neutron capture therapy at Tsing Hua open-pool reactor started on August 11, 2010. Up to January 2014, 17 patients were treated. Based on the treatment planning experiences of clinical trials using in-house designed THORplan, different setups should be used for superficial and deep-seated tumors. Superficial tumor treatment gains benefits from the use of patient collimator, while direct irradiation is a better choice for deep-seated tumor.