2014 Article Clinical trials ICNCT15 Recurrences Toxicity

BNCT for advanced or recurrent head and neck cancer

Applied Radiation and Isotopes, 2014

Authors:   Teruhito Aihara,Norimasa Morita,Nobuhiko Kamitani,Hiroaki Kumada,Koji Ono,Junichi Hiratsuka,Tamotsu Harada,
Journal: Applied Radiation and Isotopes
Abstract: The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC.