Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

Authors:   Martti Kulvik,Merja Kallio,Juha Laakso,Jyrki Vähätalo,Raine Hermans,Eija Järviluoma,Anders Paetau,Merja Rasilainen,Inkeri Ruokonen,Matti Seppälä,Juha Jääskeläinen,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.08.006
Abstract: We studied the uptake of boron after 100mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.