2015 Article ICNCT16 In-vivo Studies Others Radiobiology

Antitumor efficacy of extracellular complexes with gadolinium in Binary Radiotherapy

Applied Radiation and Isotopes, 2015

Authors:   A.A. Lipengolts,A.A. Cherepanov,V.N. Kulakov,E.Yu. Grigorieva,I.N. Sheino,V.A. Klimanov,
Journal: Applied Radiation and Isotopes
Abstract: In this report the efficacy of extracellular pharmaceutical Gd-DTPA in Binary Radiotherapy was studied. The study was carried out in mice bearing transplantable adenocarcinoma Ca755 using X-ray based contrast enhanced radiotherapy as a practical implementation of Binary Radiotherapy. It was shown that intravenous administration of 0.3ml of 0.5M water solution of Gd-DTPA followed by X-irradiation at a dose of 10Gy provides T/C%=10±3% and leads to complete tumor regression in 25% of mice.