Additive effect of BPA and Gd-DTPA for application in accelerator-based neutron source

Authors:   F. Yoshida,T. Yamamoto,K. Nakai,A. Zaboronok,A. Matsumura,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2015.07.030
Abstract: Because of its fast metabolism gadolinium as a commercial drug was not considered to be suitable for neutron capture therapy. We studied additive effect of gadolinium and boron co-administration using colony forming assay. As a result, the survival of tumor cells with additional 5ppm of Gd-DTPA decreased to 1/10 compared to the cells with boron only. Using gadolinium to increase the effect of BNCT instead of additional X-ray irradiation might be beneficial, as such combination complies with the short-time irradiation regimen at the accelerator-based neutron source.