A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba

Authors:   H. Aiyama,K. Nakai,T. Yamamoto,T. Nariai,H. Kumada,E. Ishikawa,T. Isobe,K. Endo,T. Takada,F. Yoshida,Y. Shibata,A. Matsumura,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.04.031
Abstract: We have evaluated the efficacy and safety of boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor using a new protocol. One of the two patients enrolled in this trial is a man with recurrent glioblastoma and the other is a woman with anaplastic meningioma. Both are still alive and no severe adverse events have been observed. Our findings suggest that NCT will be safe as a palliative therapy for malignant brain tumors.