2014 Accelerators Article ICNCT15 Physics

9Be(d,n)10B-based neutron sources for BNCT

Applied Radiation and Isotopes, 2014

Authors:   M.E. Capoulat,M.S. Herrera,D.M. Minsky,S.J. González,A.J. Kreiner,
Journal: Applied Radiation and Isotopes
Abstract: In the frame of accelerator-based BNCT, the 9Be(d,n)10B reaction was investigated as a possible source of epithermal neutrons. In order to determine the configuration in terms of bombarding energy, target thickness and Beam Shaping Assembly (BSA) design that results in the best possible beam quality, a systematic optimization study was carried out. From this study, the optimal configuration resulted in tumor doses ≥40Gy-Eq, with a maximum value of 51Gy-Eq at a depth of about 2.7cm, in a 60min treatment. The optimal configuration was considered for the treatment planning assessment of a real Glioblastoma Multiforme case. From this, the resulted dose performances were comparable to those obtained with an optimized 7Li(p,n)-based neutron source, under identical conditions and subjected to the same clinical protocol.