10B-NMR determination of 10B-BPA, 10B-BPA–fructose complex and total 10B in blood for BNCT

Authors:   K. Yoshino,T. Yabe,T. Hattori,K. Saito,A. Ishikawa,H. Ohki,
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2013.12.020
Abstract: First spontaneous, noninvasive determination method of 10B-BPA, 10B-BPA–fructose complex, and total 10B in blood is described. 10B-NMR measurement with 100,000 FT accumulation enables us to obtain the result within 100min/sample. The detection limits for the simultaneous analysis were 3ppm, 3ppm and 6ppm for 10B-BPA, 10B-BPA–fructose complex and total 10B respectively in this study. By this method, we can actually discuss behavior of the 10B-BPA–fructose complex in blood.