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2020 Article Boron Compounds Chemistry ICNCT18 Special Issue(ARI)

Optimization of preparation methods for high loading content and high encapsulation efficiency of BSH into liposomes

Applied Radiation and Isotopes, 2020

Authors:   Shirakawa M., Nakai K., Sato Y. Nakamura S., Harada M., Ishihara K., Yoshida F., Matsumura A., Tomida H.
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2020.109260
Abstract: To optimize the preparation methods for liposomes encapsulating mercaptoundecahydrododecaborate (BSH), we examined BSH and lipid concentrations that increased the boron content in liposomes. We improved the BSH encapsulation efficiency and boron content of the liposomes from 4.2 to 45.9 % and 9.5–54.3 ?g, respectively, by changing the lipid concentration from 10 to 150 mg/mL. Notably, the boron content increased significantly from 26.2 ?g to 326.3 ?g at a constant lipid concentration of 30 mg/mL with increased BSH concentrations.

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